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KMID : 1137820090300050444
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의공학회지
2009 Volume.30 No. 5 p.444 ~ p.451
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Longitudinal Alterations of Microarchitecture and Mineralization Distribution on Trabecular Bone Due to Metastatic Bone Tumor
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Park Sun-Wook
Jeon Ok-Hee
Ko Chang-Yong
Kim Chi-Hyun
Kim Han-Sung
Chun Keyong-Jin
Lim Do-Hyung
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Abstract
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Purpose: The aim of present study is to detect longitudinal alterations of mechanical characteristic determined by bone quality (microarchitecture and degree of mineralization) on femur trabecular bone due to metastatic bone tumor
Materials and Methods: Each 6 female SD rats (12 weeks old, approximate 250g) were allocated in SHAM and TUMOR Group. W256 (Walker carcinosarcoma 256 malignant breast cancer cell) was injected into the right femur (intraosseous injection) in TUMOR Group, whereas 0.9% NaCl (saline solution) was injected in SHAM Group. The right hind limbs of all rats were scanned by in-vivo micro-CT to acquire structural parameters, bone mineral density, X-ray attenuation and bone mineralization distribution at 0 week and 4 weeks after surgery.
Results: BMD, BV/TV and Tb.N of trabecular bone in TUMOR group were markedly decreased (26%, 11% and 23%) while those in SHAM group were significantly increased (34%, 48% and 11%) (p<0.05). BS/BV, Tb.Sp and SMI in TUMOR group were significantly increased (-16%, 38% and 2%) compared with those in SHAM group (-33%, 12% and -16%) (p<0.05). Additionally, bone mineralization in TUMOR group significantly decreased while those in SHAM group was significantly increased (p<0.05).
Conclusion: It is identified that how much bone microarchitecture and mineralization are diminished due to the metastatic bone tumor. The results may be helpful to prediction of fracture risk by metastatic bone tumor.
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KEYWORD
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Metastatic bone tumor, Bone qualities, Structural parameters, Bone mineralization, In-vivo micro-CT
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